Indications: Treatment and maintenance therapy of active duodenal ulcer. Treatment of benign gastric ulcers. Treatment of reflux oesophagitis. Treatment of pathological hyper secretoryconditions (Zoltinger-Elllson Syndrome) Contra-indications: Cimetidine (HCI) is contraindicated in conditions like Hypersensitivity. Adverse Effects: Adverse reactions to cimetidine are generally infrequent and ars usually reversible following a reduction of dosage or withdrawal of therapy. The commonest side-effects reported have been altered bowel habit, dizziness, tiredness, headache and rashes, Reversible confusional states, especially in the elderly or in seriously ill patients such as those with renal failure, have occasionally occurred, Cimetidine has a weak anti-androgenic effect and gynaeconnastia and impotence have also occasionally occurred in men receiving relatively high doses for conditions such as the Zollinger-Ellison syndrome, Other adverse effects which have been reported rarely are hypersensitivity reactions and fever, arthralgia and myalgia, blood disorders including agranulocytosis and thrombocytopenia, interstitial nephritis, hepatotoxicity and cardiovascular disorders including bardycardia and heart block. Dosage: Cimetidine should be administered preferably after meals or at bed time. Doses should be adjusted to individual patients needs & should continue as long as clinically indicated.